Which of the following will not give Hoffmann | vedclass

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Question

(D) The Hoffmann bromamide degradation reaction is specifically given by primary amides $(R-CONH_2)$ to form primary amines with one less carbon atom.

Vedclass · Accepted Answer

$C_6H_5CONHCH_3$

Vedclass · Answer

(D) The Hoffmann bromamide degradation reaction is specifically given by primary amides $(R-CONH_2)$ to form primary amines with one less carbon atom.This reaction requires two hydrogen atoms on the nitrogen atom of the amide group to proceed through the mechanism involving the formation of an isocyanate intermediate.Secondary amides $(R-CONHR)$ and tertiary amides $(R-CONR_2)$ do not undergo this reaction because they lack the necessary two hydrogen atoms on the nitrogen.In the given options,$C_6H_5CONHCH_3$ is a secondary amide ($N$-methylbenzamide),which lacks the two hydrogen atoms on the nitrogen required for the reaction. Therefore,it will not give the Hoffmann bromamide reaction.

Which of the following will not give Hoffmann bromamide reaction?

Similar Questions

Identify the products $y$ and $x$ in the following reaction sequence:
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